Soy Nutrition Institute
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Nov 30, 2012

Isoflavones alleviate hot flashes: Results of a new clinical trial

Research confirms the ability of isoflavones to alleviate hot flashes.  In this study 130 healthy Italian postmenopausal women were randomized to either the placebo (calcium and vitamin D) or isoflavone (60 mg/d) group for one year.  Hot flashes as well as other menopausal symptoms were monitored every three months.  In addition, several safety measures were evaluated.  At the first time point, there was a statistically significant 34% reduction in hot flash severity (severity was assessed using a 5 point scale; 0= absent; 1= mild; 2= moderate; 3= severe; 4= very severe) in the isoflavone group versus only a 2.7% decrease in the placebo group.  Furthermore, the difference between the two groups increased over the course of the study.  Women consuming the isoflavone supplements also experienced improvements in vaginal dryness and libido.  Importantly, isoflavones didn’t affect mammographic density, endometrial thickness or liver function.  Thus, the results indicate isoflavones are a safe approach for alleviating menopausal hot flashes.

Colacurci N, De Franciscis P, Atlante M, et al. Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women. Gynecol Endocrinol 2012.