Isoflavones have been associated with lower cardiovascular disease risk in Asian studies. The current investigation evaluated whether low isoflavone intake among premenopausal women is associated with serum C-reactive protein (CRP) concentration, a commonly used biomarker associated with prediction of cardiovascular disease risk in healthy women. Between 2005 and 2007, 259 healthy, regularly menstruating women were enrolled in the BioCycle Study, and followed for up to 2 menstrual cycles. CRP was measured in serum at up to 16 clinic visits, timed to phases of the women's menstrual cycle. Diet was assessed up to 4 times per cycle by using 24-h recalls. Analysis indicates that compared with women in the lowest quartile of total isoflavone intake, women in the highest quartile had, on average, 27% lower serum CRP concentrations.
Filiberto et al. J Nutr 2013