Results of a 3-year trial found that 300 mg/d of a combination consisting of 2/3 soy phytosterols and 1/3 avocado phytosterols reduced the number of hip osteoarthritis patients whose condition had worsened (patients whose loss of joint space width was 0.5 mm or more) over the study period. Osteoarthritis is the most common joint disorder, with hip OA being reported by one in 10 individuals older than 65.
Maheu E, Cadet C, Marty M, et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis 2014;73:376-84.