The usefulness of animal studies for predicting effects in humans is a hotly debated topic. Consequently, whether the finding that soybean saponins improved chemically-induced memory impairment in mice will be replicated should clinical studies be conducted is unclear. Nevertheless, this study serves to illustrate that classically-defined “antinutrients” can have beneficial effects.
Hong SW, Yoo DH, Woo JY, et al. Soyasaponins Ab and Bb Prevent Scopolamine-Induced Memory Impairment in Mice without the Inhibiton of Acetylcholinesterase. J Agric Food Chem 2014;