For decades, the mainstream view has been that an elevated level of total cholesterol is a primary cause of atherosclerosis and cardiovascular disease. However, less clear is the relationship between total cholesterol and LDL-cholesterol among older individuals. To address this relationship, researchers examined the relationship between LDL-cholesterol and all-cause mortality and cardiovascular disease mortality among 29 cohorts that involved 68,094 people at least 60 years of age. An inverse association between all-cause mortality and LDL-C was seen in 16 cohorts representing 92% of the number of participants, where this association was recorded. In two cohorts, cardiovascular disease mortality was highest in the lowest LDL-C quartile and with statistical significance; in seven cohorts, no association was found. In conclusion, high LDL-C is inversely associated with mortality in most people over 60 years.
Ravnskov U, Diamond DM, Hama R, Hamazaki T, Hammarskjold B, Hynes N, Kendrick M, Langsjoen PH, Malhotra A, Mascitelli L, McCully KS, Ogushi Y, Okuyama H, Rosch PJ, Schersten T, Sultan S, and Sundberg R. Lack of an association or an inverse association between ow-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open 2016;6:e010401.